5 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Nonspecific inhibitors e.g ... to one factor e.g ... inhibitory drugs e.g ... Nonspecific inhibitor e.g ... Causes #diagnosis #differential
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Pre-analytical cause (e.g ... inhibitory drugs (e.g ... specific inhibitor (e.g ... amyloidosis #Abnormal
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... may be normal in ... hemophilia type (e.g ... #hematology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
not be subtle e.g ... very remarkable w/differential ... E.g. 80 yo ESR cutoff ... Treatment of GCA ... them, but urgent rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... • Malignancy (e.g ... Endocrine disorders (e.g ... meningitis • Cranial