6 results
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood culture ... whipplei, Fungi (Aspergillus ... , Candida), Mycoplasma ... #Microbiology #CNIE ... #BCNIE #cardiology
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... separate blood cultures ... whipplei, Fungi (Aspergillus ... , Candida), Mycoplasma ... - Standard culture
Common Fungal Pathology 
 • Candida - Small yeast intermingled with pseudohyphae
 • Aspergillosis - Septate
Pathology • Candida ... Pathology #clinical #microscopy ... #table #atlas # ... key #comparison
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS ... 90% of IE cases Culture ... Tropheryma Whipplei • Aspergillus ... • Blood cultures ... diagnosis #management #cardiology
Important Fungal Stains
Mycology Lab:
 • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... exceptions are Aspergillus ... #microbiology #microscopy ... fungi #fungus #comparison
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
Hypercoagulable (APLAS ... 90% of IE cases Culture ... staphylococci Culture ... Tropheryma Whipplei • Aspergillus ... Differential #Diagnosis #cardiology