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diagnosis endocarditis differential infectiousdiseases bcnie fungal infective microbiology bacteria betadglucan biomarkers bloodculture causes cnie fungus galactomannan incidence management pathogens staining
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
bacilli - Fungi ... (Candida, Aspergillus ... Histoplasma) - Culture ... bacilli - Fungi ... streptococci - Culture
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
negative infective ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... #negative #Endocarditis ... #CNIE #BCNIE #cardiology
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... remain negative ... fastidious bacteria or fungi ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... exceptions are Aspergillus ... • India ink - "Negative ... #microbiology #microscopy ... #fungus #comparison
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
component of many fungi ... • Pathogens: Candida ... Coccidioides - Negative ... closely related fungi ... Galactomannan #diagnosis #comparison
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Hypercoagulable (APLAS ... • Coagulase-negative ... Tropheryma Whipplei • Aspergillus ... • Blood cultures ... diagnosis #management #cardiology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Hypercoagulable (APLAS ... aureus, Coagulase-negative ... Negative: • Bartonella ... Tropheryma Whipplei • Aspergillus ... Differential #Diagnosis #cardiology
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