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infectiousdiseases differential cardiology infective negative algorithm bcnie fungal microbiology bacteria bloodculture bloodcultures bloodstream catheter causes cnie comparison crbsi fungi fungus
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
with Infective Endocarditis ... Fungal (Histoplasma/Aspergillus ... patient a surgical candidate ... BloodCultures #Diagnosis ... #Management #Algorithm
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
for Infective Endocarditis ... bacilli - Fungi (Candida ... , Aspergillus, Histoplasma ... ) - Culture negative ... Bacteria #Pathogens #Diagnosis
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
negative infective endocarditis ... whipplei, Fungi (Aspergillus ... , Candida), Mycoplasma ... #differential #diagnosis ... #negative #Endocarditis
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Hypercoagulable (APLAS ... Tropheryma Whipplei • Aspergillus ... Differential Diagnosis ... Diagnosis? ... #diagnosis #management
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Infective Endocarditis ... whipplei, Fungi (Aspergillus ... , Candida), Mycoplasma ... BCNIE Diagnostic ... #diagnosis #differential
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
and Differential Diagnosis ... Hypercoagulable (APLAS ... Tropheryma Whipplei • Aspergillus ... Marantic (NTBE) Diagnosis ... #Differential #Diagnosis
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... exceptions are Aspergillus ... #microbiology #microscopy ... #staining #diagnosis ... fungus #comparison #table
Suspected catheter-related bloodstream infection - Management Algorithm • Temperature 37.8 C • Rigors
Obtain blood cultures ... Hemodynamically stable ... metastatic infection (endocarditis ... Hernodynamically stable ... Algorithm #CRBSI #diagnosis
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
• Confirmed by culture ... ASPERGILLOSIS • Aspergillus ... : • Culture of ... arthritis, and endocarditis ... #Management #Infections
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