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diagnosis symptoms endocrinology gh management anomalous bone bony cardiology causes complications excess feedbackloop gait knee lesions lfcn meralgiaparesthetica myelitis neurology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... expansion (e.g. carpal ... metabolic abn #GrowthHormone ... endocrinology #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... overgrowth: • Carpal ... fraction • HTN #GrowthHormone ... Overproduction #diagnosis #signs ... endocrinology #pathophysiology
Total Anomalous Pulmonary Venous Return (TAPVR) • Introduction • Classification • Pathophysiology of TAPVR • Presentation
Classification • Pathophysiology ... Classic “snowman sign ... Outcomes by Cara ... cardiology #peds #pediatrics
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
in the Spinal canal ... Trendelenburg #Gait #pathophysiology ... causes #symptoms #signs ... #diagnosis #msk
Meralgia paresthetica: Pathogenesis and Clinical Findings Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica •
MeralgiaParesthetica #MSK ... #pathophysiology ... #differential # ... diagnosis #signs
Diagram of different types of bone tumors that can occur around the knee on XRay Age <
blade of grass sign ... Lesions #Bony #Differential ... Radiology #XRay #MSK ... #pediatrics
Scoliosis: Pathogenesis and clinical findings (Cobb Angle > 10 Degrees) • Incr Axial rotation of thoracic
intervertebral canal ... #Scoliosis #pathophysiology ... #msk #diagnosis ... #signs #symptoms
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
10-33% develop MS ... monophasic Pathophysiology ... • Bilateral signs ... Predictive of MS ... management #neurology #differential
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
bone formation MSK ... the vertebral canal ... PagetsDisease #pathophysiology ... #diagnosis #signs
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