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Cephalosporins - Antibiotics Class Overview
1st Generation 
 - Cefazolin (Ancef, Kefzol) - IV
 - Cephalexin (Keflex)
Ceftriaxone (Rocephin ... Ceftazidime (IV) ... Cephalexin #Cefuroxime #Ceftriaxone ... #Cefpodoxime #Ceftazidime
Cephalosporin Antibiotics
 • First Generation: Cefazolin, Cefadroxil, Cephalexin
 • Second Generation: Cefuroxime sodium, Cefuroxime axetil
 •
Cefixime, Cefotaxime, Ceftazidime ... , Ceftibuten, Ceftriaxone
Cephalosporins - Table of Coverage by Generation

1st Generation   Cefazolin, cephalexin 
2nd Generation Cefotetan 
3rd
3rd Generation Ceftriaxone ... , Cefpodoxime Ceftazidime ... Coverage #Generation #Ceftriaxone
Cephalosporin Antibiotic Generations - Mnemonic
1st Generation "FA/PHA": CEFAZOLIN, CEFADROXIL, CEPHALEXIN, CEPHALOTHIN, CEPHAPIRIN, CEPHRADINE
2nd Generation "Everything Else":
"ONE/TEN/IME": CEFTRIAXONE ... CEFTIBUTEN, CEFOTAXIME, CEFTAZIDIME
Cephalosporin Comparison - Coverage 
1st Generation Cefazolin, Cephalexin 
2nd Generation Cefaclor, Cefotetan, Cefoxitin, Cefuroxime 
3rd Generation
Cefixime, Cefotaxime, Ceftazidime ... , Ceftriaxone ... same coverage as Ceftriaxone
Antibiotics for severe community-onset pneumonia 

Atypical coverage always 

- Usually azithromycin 500 mg daily 

- Doxycycline
backbone - Usually ceftriaxone ... - Don't use ceftazidime
Lyme Disease: Early and Late Stage Treatment
Stage 1. Localized
 • Doxycycline, amoxicillin, cefuroxime x 10-14d
Stage 2.
CNS/carditis: ceftriaxone ... Arthritis: doxycycline/ceftriaxone ... 14-28d • CNS: ceftriaxone
Gonococcal Infections (Gonorrhea) - CDC 2021 Treatment Guidelines
Recommended Regimen:
 • Uncomplicated infections of the cervix, urethra,
adolescents <150 kg ceftriaxone ... adolescents <150 kg ceftriaxone ... • Pregnancy: ceftriaxone ... Conjunctivitis: ceftriaxone ... infections (DGI): ceftriaxone
Pseudomonas aeruginosa Resistance to Beta-lactams

Standard Agents: 
Ceftazidime, Cefepime, Piperacillin-Tazobactam, Imipenem, Meropenem

MDR Agents: 
Ceftazidime-Avibactam, CeftoIozane-Tazobactam, Imipenem-Relebactam, Meropenem-Vaborbactam,
Standard Agents: Ceftazidime ... MDR Agents: Ceftazidime-Avibactam
Antibiotics used for the Treatment of Pseudomonas Aeruginosa in Adults
 • Penicillin-beta-lactamase combinations: Piperacillin-tazobactam, Ticarcillin-clavulanate
 •
Cephalosporins: Ceftazidime ... combinations: Ceftazidime-avibactam