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diagnosis differential algorithm anemia hematology copper disease evaluation fe gastrointestinal malabsorption management mds myelodysplasia myelodysplastic oncology pancreatitis syndromes thrombocytosis treatment
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Drugs, H pylori, Celiac ... Inflammation: IBD ... , Chronic disease ... #Deficiency #Causes
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Elite athletes • Chronic ... Bleeding, Edema, Celiac ... Inflammatory Disease (IBD ... #nutrition
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
Suspected Celiac ... disease • Iron-deficiency ... without discernable cause ... Inflammatory (IBD ... Diagnosis #Algorithm #gastroenterology
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Deficiency Anemia ... inflammation or chronic ... tests Test for celiac ... Gastrointestinal #Evaluation #workup ... #diagnosis #gastroenterology
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... cancer, ulcer, IBD ... Increased hepcidin: Chronic ... of absorption): Celiac ... #Diagnosis #Causes
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Inflammatory: • IBD ... disorders • Celiac ... malignancy • Iron ... deficiency anemia
Causes of Copper Deficiency - Differential Diagnosis Hereditary: - Menkes disease, familial hypoceruloplasminemia Decreased / Inadequate Intake:
Causes of Copper ... Deficiency - Differential ... ulcerative colitis, Crohn's ... disease, Celiac ... supplementation) or iron
Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver
Causes of Fat Malabsorption ... • Autoimmune— Crohn's ... - Acquired • Chronic ... Pancreatic lipase deficiency ... disease • IBD
Chronic Pancreatitis Definition: A pathologic fibroinflammatory syndrome of the pancreas in individuals with genetic, environmental, and/or other
Chronic Pancreatitis ... stress. 60% of CP cases ... Abdominal pain • Fat-soluble ... vitamin deficiency ... diagnosis #management #gastroenterology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Mean age at Dx ... Marrow Failure • Chronic ... Platelet Disorders • Nutritional ... rings of excess iron
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