11 results
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Cell Disease - Pathophysiology ... damage leading to calcium ... Calcium influx leads ... SickleCell #Disease #Pathophysiology ... Complications #Hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Lysis Syndrome: • Pathophysiology ... Elevated Cr, Low calcium ... treatment (no calcium ... diagnosis #management #hematology
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
> Clearance of calcium ... mineralization of calcium ... joint (sudden onset ... Signs #Symptoms #Pathophysiology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... precipitates with calcium ... characterized by sudden onset ... • Nocturnal onset ... Gout #Comparison #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... SLE+++, Adult-onset ... treatment #summary #rheumatology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
4) Average age onset ... survival is 93-95% Pathophysiology ... fibrosis. 4) Calcium
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
resembles ARDS, onset ... binds to serum calcium ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
resembles ARDS, onset ... binds to serum calcium ... diagnosis #management #hematology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Pseudogout Summary - Calcium ... Disease (CPPD) Pathophysiology ... precipitates with calcium ... characterized by sudden onset ... Deposition #Disease #Rheumatology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
injury 2) Abrupt onset ... anemia (MAHA) Pathophysiology ... Renal #Crisis #rheumatology