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diagnosis management hematology cppd disease product reactions comparison complications deposition gout hemophagocytic hlh lymphohistiocytosis pseudogout pyrophosphate sequelae sicklecell summary transfusion
Sickle Cell Disease - Pathophysiology of disease and complications Due to the deformed shape, HbS induces
Cell Disease - Pathophysiology ... damage leading to calcium ... Calcium influx leads ... obstructing and reducing blood ... Complications #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Phagocytosis of blood ... SLE+++, Adult-onset ... treatment #summary #rheumatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... screen - determines blood ... resembles ARDS, onset ... binds to serum calcium ... diagnosis #management #hematology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... precipitates with calcium ... characterized by sudden onset ... • Nocturnal onset ... Gout #Comparison #rheumatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... the banked donor blood ... resembles ARDS, onset ... binds to serum calcium ... diagnosis #management #hematology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Pseudogout Summary - Calcium ... Disease (CPPD) Pathophysiology ... precipitates with calcium ... characterized by sudden onset ... Deposition #Disease #Rheumatology
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