7 results
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
produced, incr gut ... > Clearance of calcium ... (sudden onset) ... Disease #Signs #Symptoms ... #Pathophysiology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
or nerve root Symptoms ... Monosodium urate • Calcium ... dihydrate • Basic calcium ... hydroxyapatite) • Calcium ... #Pain #MSK #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
constitutional symptoms ... - Autoimmune Rheumatologic ... arthritis • Adult onset ... Differential #Diagnosis #MSK ... #rheumatology #
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... precipitates with calcium ... characterized by sudden onset ... • Nocturnal onset ... #Comparison #rheumatology
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
deposition in joints ... attacks • Other joints ... • Nocturnal onset ... Dual-energy CT → MSU ... management #treatment #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... Nervous System: • Onset ... • Progressive symptoms ... Palpable purpura, joint ... Differential #Diagnosis #Rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Disease (CPPD) Pathophysiology ... swelling in weird joints ... characterized by sudden onset ... MCP or shoulder joints ... Deposition #Disease #Rheumatology