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diagnosis differential management arthritis cppd disease msk pseudogout vasculitis workup alkaline alp approach autoimmune chondrocalcinosis classification comparison deposition erythematosus hepatology
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
or nerve root Symptoms ... Monosodium urate • Calcium ... dihydrate • Basic calcium ... hydroxyapatite) • Calcium ... #Pain #MSK #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
constitutional symptoms ... Crystal induced (Gout ... - Autoimmune Rheumatologic ... arthritis • Adult onset ... Diagnosis #MSK #rheumatology
Pseudogout: pathogenesis and clinical findings - Idiopathic (vast majority of cases) -> Mechanism unknown - Familial
produced, incr gut ... > Clearance of calcium ... (sudden onset) ... Disease #Signs #Symptoms ... #Pathophysiology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... precipitates with calcium ... of swelling, pain ... • Nocturnal onset ... #Comparison #rheumatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
prematurely • risk of joint ... collection with EDTA Pathophysiology ... ALP -> PPi and Calcium ... mineralization Symptoms ... (muscle/joint)
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
to a more rapid onset ... relatively chronic onset ... infections, bone pain ... , fever, joint pain ... #Leukemia #Hematology
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
deposition in joints ... attacks • Other joints ... • Nocturnal onset ... swelling, significant pain ... management #treatment #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... synovial fluid • Gout ... urate crystals (gout ... , and low back pain ... diagnosis #testing #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
arthritis, adult-onset ... Arthritis: • Joint ... pain • Swan neck ... Induced Lupus: • Symptoms ... Erythematosus #Diagnosis #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Nervous System: • Onset ... • Progressive symptoms ... Palpable purpura, joint ... , abdominal pain ... Differential #Diagnosis #Rheumatology
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