13 results
Sickle Cell Vaso-Occlusive Crisis

#SickleCell #Crisis #Vasoocclusive #AcuteChestSyndrome #ACS #Pathophysiology #Hematology
Vaso-Occlusive Crisis ... #SickleCell #Crisis ... AcuteChestSyndrome #ACS #Pathophysiology ... #Hematology
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Diffuse, Renal crisis ... , Young age of onset ... Autoantibodies #diagnosis #rheumatology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Cell Disease - Pathophysiology ... sickling.Vaso-occlusive crisis ... SickleCell #Disease #Pathophysiology ... Complications #Hematology
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
joints (shoulders, wrists ... disease states Pathophysiology ... characterized by sudden onset ... • Nocturnal onset ... Gout #Comparison #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... SLE+++, Adult-onset ... treatment #summary #rheumatology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
Scleroderma Renal Crisis ... Scleroderma Renal Crisis ... injury 2) Abrupt onset ... anemia (MAHA) Pathophysiology ... #rheumatology #
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
to a more rapid onset ... relatively chronic onset ... -> AML: Blast crises ... #Leukemia #Hematology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
infection that cross-reacts ... • Onset: few days ... after symptom onset ... the underlying pathophysiology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
• Hypertensive crisis ... Etiology: • Pathophysiology ... symptoms: Acute onset
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
resulting in rapid onset ... monophasic Pathophysiology ... than 2/3 of the cross-sectional