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Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Hypermagnesuria, Hypomagnesemia ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Hypomagnesemia - ... Renal Causes of Hypomagnesemia ... Bartter syndrome and Gitelman ... , Familial hypomagnesemia ... diagnosis #causes #nephrology
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... hypokalemia, mild hypomagnesemia ... potassium wasting) • Hypomagnesemia ... Syndrome #diagnosis #nephrology ... #management #pathophysiology
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm
GI Losses - Gastric
 • Vomiting
 • NG suction
GI
loop/thiazide) • Hypomagnesemia ... • Barrter's/Gitelman's ... MetabolicAlkalosis #NonGap #Nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Renal K loss • Hypomagnesemia-induced ... Bartter's syndrome, Gitelman's ... algorithm #causes #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Bartter syndrome, Gitelman ... syndrome, Hypomagnesemia ... urine #Algorithm #nephrology
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypokalemia - Hypomagnesemia ... dr_missyhanna #Gitelman ... Diagnosis #Workup #nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Alcoholism (worsened by hypomagnesemia ... diuretic use), Gitelman's ... Fever Other: - Hypomagnesemia ... differential #diagnosis #nephrology