14 results
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Non-Malignant • Fatty Liver ... • Budd-Chiari Syndrome ... • Primary Biliary ... Cirrhosis #Hepatomegaly ... #Causes #Hepatology
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
- Wilson disease ... Hemochromatosis - Primary ... biliary cholangitis ... #Differential # ... Hepatology #Diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... disease, Hepatic ... biliary cholangitis ... #hepatology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
congenital - Primary ... biliary cirrhosis ... #Differential # ... Hepatology #Cirrhosis ... #Causes
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... intralobular bile ducts causes ... Viral hepatitis, ... #Biliary #Cirrhosis
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
- Hepatic: • Cirrhosis ... • Infiltrative disease ... • Acute liver ... biliary cholangitis ... #Hepatology #causes
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
Clues to non-cirrhotic ... /acute hepatitis ... pregnancy • Primary ... biliary cirrhosis ... #Diagnosis #causes
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Vascular Causes ... • Iatrogenic: DILI ... : < 1 • Cirrhosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Cholestatic disease ... Duct Stone • Biliary ... • Others #LFTs ... #Causes
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
INR > 1.5 • Encephalopathy ... : < 1 • Cirrhosis ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential #