13 results
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
fingertips ("mechanic’s hands ... auricular papules Clinical ... • Arthralgia/arthritis ... • Mechanic's hands ... #dermatology #diagnosis
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
clinical findings ... processes occur in the skin ... dorsum of the hands ... Pathophysiology #Signs ... #Symptoms #Vasculitis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... purpura: Strong sign ... occasional oligoclonal bands ... #Differential #Diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... association • M > F Clinical ... response to local skin ... Behcet syndrome (Clinical ... #management #signs
Kawasaki Disease: Clinical Findings
Diagnostic Criteria - Fever and 4/5 of the following:
 • Conjunctivitis
 • Polymorphous
Kawasaki Disease: Clinical ... Edema/erythema on hands ... : - Coronary Arteritis ... - Generalized Skin ... #Symptoms #Vasculitis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Clinical Findings ... histopathologic term ... Arthralgia's (common), arthritis ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Lymphocutaneous Sporotrichiosis Infection

Landscaper w/ painless nodular rash of arm present for months wax and wane; diagnosis?
Lymphocutaneous
wane; diagnosis ... trauma leads to skin ... painless, no systemic signs ... Sporotrichiosis #Infection #clinical ... #photo #hand
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... systemic sx + signs ... = vasculitis vs ... variably: On one hand ... required due to skip
Cushing's Syndrome - Moon Facies, Buffalo Hump, Abdominal Striae, Thin Skin

A young man presents with rapid
Abdominal Striae, Thin Skin ... the patient's hand ... Cushings #Syndrome #Signs ... BuffaloHump #Striae #Clinical ... #Photo
Secondary Syphilis Rash
Secondary syphilis is the most contagious of all the stages of this disease, and
Skin rash and malaise ... The signs and symptoms ... the palms of the hands ... Syphilis #Rash #Diagnosis ... #Clinical #Photo