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anticoagulation diagnosis doac pharmacology differential noac ptt rivaroxaban thrombin abnormal anticoagulant aptt bleeding bruising causes clot coumadin edoxaban effects fondaparinux
Coagulation cascade and anticoagulants Satyendra Dhar MD, @DharSaty #coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade ... and anticoagulants ... #coumadin #heparin ... #warfarin #apaxiban ... thrombin #ptt #pt
Coagulation Cascade - Actions of Anticoagulants • Heparin: Unfractionated heparin, Enoxaparin, Daltaparin • Fondaparinux • Direct
Coagulation Cascade ... : Rivaroxaban, Apixaban ... K Antagonists: Warfarin ... Inhibitors: Argatroban, Dabigatran ... #Cascade #Anticoagulants
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
on Coagulation ... Tests PT / INR, ... Clotting Time Warfarin ... UFH LMWH Fondaparinux ... Rivaroxaban Apixaban
Anticoagulants Common Reversal Agents - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra) - Heparin/LMWH
Anticoagulants Common ... Reversal Agents - Warfarin ... /LMWH → Protamine ... sulfate - Dabigatran ... (Praxbind) - Apixaban
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
- Pathophysiology ... (e.g. warfarin) ... #Heparins #LMWH ... #UFH #DOAC #Dabigatran ... #Apixaban #Rivaroxaban
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
#Coagulation #Cascade ... thrombin #clot #PT ... #pathophysiology ... #Warfarin #Dabigatran ... thrombin #inhibitor #Apixaban
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early warfarin therapy ... - Rivaroxaban, apixaban ... - Other anticoagulants ... Supratherapeutic warfarin ... #differential #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
integrity Clotting cascade ... Acquired: • Heparin ... , dabigatran, argatroban ... (warfarin, direct ... Differential #Diagnosis #Hematology
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