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diagnosis hematology differential hemophagocytic hlh lupus lymphohistiocytosis signs sle treatment activation behcet disease druginduced hemeonc leukostasis lysis mas polychondritis prs
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Syndrome (MAS) ... Systemic lupus erythematosus ... systemic lupus erythematosus ... #Diagnosis #Management ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... 5% of patients Cardiac ... Cytopenias • Cardiac ... Induced Lupus: • Symptoms ... #Diagnosis #Rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... lethargy, hematuria, cardiac ... with tetany or cardiac ... TLS #diagnosis #management ... #hematology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... dysregulation: activated macrophages ... neuropathy or cardiac ... Sarcoidosis #Diagnosis #Management ... #Signs #Symptoms
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... constitutional symptoms ... Systemic Lupus Erythematosus ... druginduced #lupus #sle #comparison ... #table #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... with excessive macrophage ... HLH signs and symptoms ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
meningitis), MCC CNS symptoms ... thrombosis, VTE) • Cardiac ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
nose deformity • Cardiac ... (UPC) ratio • Cardiac ... or serologies + symptoms ... hemosiderin laden macrophages ... differential #diagnosis #management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... ischemia • Skin: Erythematous ... • Progressive symptoms ... nose, tracheal collapse ... Differential #Diagnosis #Rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
ethnicities Symptoms ... Complications: • Airway collapse ... vessel aneurysms • Cardiac ... Polychondritis #rheumatology ... #diagnosis #management
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