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diagnosis differential management gastroenterology injury causes chronic cirrhosis hepatitis transaminitis abnormal aclf aflp albumin alcoholic ascites bariatric bypass calling cancer
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Hepatopathy • Acute ... (>1000): • DILI ... Function #Tests #LFTs ... Differential #Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Drug #induced #Liver ... gastroenterology #algorithm ... gastroenterology #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... ACLF) Clinical Guidelines ... months without treatment ... Injury (DILI) ... Failure #Cirrhosis #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... dechallenge • Acute ... Injury #Diagnosis #Algorithm ... #hepatology
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
The Liver Consult ... - Cirrhosis & complications ... - Vitals - LFTs ... GTT, indirect bili ... Calling #Referral #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... vein: Budd-chiari syndrome ... • Iatrogenic: DILI ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Unconjugated Bili ... • Gilbert's syndrome ... #differential #Hepatology ... transaminitis #LFTs
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... → Refer to hematology ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... #hematology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... headache, malaise) → Acute ... 10x ULN), ↑Tbili/Dbili ... Monitor and Treat Complications ... #Pregnancy #hepatology
Indications for Albumin for Management of Cirrhosis • Large volume paracentesis (>5 liter) - 8g per
) - 8g per liter ... ascites removed • Acute ... • Hepatorenal syndrome ... Management #Cirrhosis #treatment ... #hepatology
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