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diagnosis differential management causes infections brain treatment betadglucan galactomannan latenttb tb tuberculosis abscess antibiotic aspergillus biomarkers comparison failure falsepositives fever
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: ... Double-stranded RNA • Fungi ... vasculature via: • Active ... #Pathophysiology ... #InfectiousDiseases
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Fever - Pyrogen Pathophysiology ... EXOGENOUS PYROGEN • Bacteria ... Lipopolysaccharide components ... stranded RNA • Fungi ... vasculature via: • Active
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... • Bacteria: Nocardia ... ) • Fungi: Aspergillus ... Diagnosis #causes #infectiousdiseases
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... • Bacteria: Nocardia ... ) • Fungi: Aspergillus ... Diagnosis #causes #infectiousdiseases
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
intracellular rod-shaped bacteria ... tuberculosis (LTBI) Pathophysiology ... infection (NTM) • Fungal ... Response: • Most bacteria ... disease, bacteremia
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... decreased with: concurrent ... admin of mold-active ... Clav (may be + as long
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
intracellular rod-shaped bacteria ... tuberculosis (LTBI) Pathophysiology ... infection (NTM) • Fungal ... Response: • Most bacteria ... disease, bacteremia
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
• Cell wall component ... Infections with certain bacteria ... Sensitivity ↓ w/concurrent ... admin mold-active ... result in + as long
Differential Diagnosis for Concurrent Brain and Lung Infections • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
Diagnosis for Concurrent ... Brain and Lung ... Infections • Bacteria ... Toxoplasmosis • Fungi ... ID_fellows #Brain #Lung
Causes of Antibiotic Failure - Differential Diagnosis Framework Diagnosis: • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Bug: Atypical bacteria ... : Viral, Fungal, ... Aggressive: MRSA bacteremia ... ocular), Tissue activity ... (daptomycin in lungs
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