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diagnosis infections management betadglucan brain causes differential galactomannan latenttb tb treatment tuberculosis aspergillus bacteremia biomarkers comparison fever humoral immunity immunology
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: ... Double-stranded RNA • Fungi ... Mannan and glucan components ... vasculature via: • Active ... #InfectiousDiseases
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
• Cell wall component ... Sensitivity ↓ w/concurrent ... admin mold-active ... result in + as long ... #Testing #FalsePositives
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... decreased with: concurrent ... admin of mold-active ... Clav (may be + as long
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Fever - Pyrogen Pathophysiology ... Lipopolysaccharide components ... stranded RNA • Fungi ... Mannan and glucan components ... vasculature via: • Active
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... ) • Fungi: Aspergillus ... #Infections #Concurrent ... Diagnosis #causes #infectiousdiseases
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... ) • Fungi: Aspergillus ... #Infections #Concurrent ... Diagnosis #causes #infectiousdiseases
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... affecting the lungs ... infection (NTM) • Fungal ... • Lymphoma • Lung ... • Progressive lung
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... affecting the lungs ... infection (NTM) • Fungal ... • Lymphoma • Lung ... • Progressive lung
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
bacteria, viruses, fungi ... helper T cells and activate ... Complement: Abs activate ... Memory B cells are long-lived ... Humoral #Immunity #pathophysiology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Aspergillosis Pathophysiology ... change in the lungs ... nails, bronchi, lungs ... ) #Mycoses #InfectiousDiseases ... #Fungal #Diagnosis
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