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AKI in Cirrhosis - Hepatorenal Syndrome Management Algorithm

DOI: 10.1136/bmj.m2687

#AKI #Cirrhosis #Hepatorenal #Syndrome #HRS #Management #Algorithm #nephrology
AKI in Cirrhosis ... - Hepatorenal Syndrome ... Management Algorithm ... #Hepatorenal #Syndrome ... #Algorithm #nephrology
 End Stage Liver Disease (Cirrhosis) - Complications 
 • Ascites
 • Esophageal Varices
 • Hepatic
Liver Disease (Cirrhosis ... Hepatopulmonary Syndrome ... (HPS) • Hepatorenal ... Syndrom (HRS) ... Complications #diagnosis #management
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... irrigation • Management ... failure, liver cirrhosis ... and nephrotic syndrome ... #Nephrology #Pharmacology
Hepatorenal Syndrome Diagnosis
 • ↑ in serum Cr of ≥ 0.3mg/dL above baseline
Hepatorenal Syndrome ... (e.g. advanced cirrhosis ... output and/or ↓ diuretic ... #Syndrome #diagnosis ... #HRS #nephrology
Hepatorenal Syndrome (HRS) - Diagnostic Criteria
HRS-AKI (Acute: previously known as HRS Type 1)
 • ↑ Creatinine
Hepatorenal Syndrome ... in 3 months • Cirrhosis ... nephrotoxics (e.g. diuretics ... drkeithsiau #HRS #Hepatorenal ... #Syndrome #diagnosis
Approach to the Hospitalized Patient with Cirrhosis
1) Recognize and Manage Decompensation
 • Ascites
 • Variceal Bleeding
Hospitalized Patient with Cirrhosis ... Alcoholic Hepatitis • Hepatorenal ... Syndrome • Prognostication ... DeanEhrlich_MD #inpatient #Cirrhosis ... diagnosis #treatment #management
Pharmacological Treatment of Hepatorenal Syndrome (HRS)

Midodrine - Alpha agonist incr blood pressure incr renal perfusion pressure
Pharmacological Treatment of Hepatorenal ... Syndrome (HRS) ... 34t5DgJ #HRS #HepatoRenal ... #Syndrome #Nephrology ... #Management #Pharmacology
Indications for Albumin for Management of Cirrhosis
 • Large volume paracentesis (>5 liter) - 8g per
for Albumin for Management ... of Cirrhosis ... antibiotics • Hepatorenal ... syndrome - 1g/ ... #Cirrhosis #treatment
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Renal losses, Diuretic ... Ketonuria, Osmotic diuresis ... Stress, Drugs, Syndrome ... , Cirrhosis, Cardiac ... Algorithm #Causes #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
• Hypovolemic: Diuretics ... osmotic (solute) diuresis ... Hypervolemic: Conn syndrome ... , Cushing syndrome ... Workup #Algorithm #nephrology