2908 results
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19

IL-6 activates T cells and macrophages, among other cell types (see
cell types (see “Cytokine ... 22% - Infusion reaction ... #Pharmacology #Management
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion Reactions ... common immune reaction ... accumulated inflammatory cytokines ... once had another reaction ... Transfusion #diagnosis #management
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
common immune reaction ... accumulated inflammatory cytokines ... once had another reaction ... - Allergic reaction ... Transfusions #diagnosis #management
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Immune Reactions ... Inhibition of cytokine ... Inhibition of cytokine
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
proinflammatory cytokines ... anti-inflammatory cytokine
Algorithm for the Evaluation and Management of Transfusion Reactions

This algorithm was developed by Dr. Eric Madden,
Evaluation and Management ... of Transfusion Reactions ... #Transfusion #Reactions ... Algorithm #Diagnosis #Management
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
eosinophilopoietic cytokines ... causes: - Drug reaction ... infection - Allergic reaction
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
hypersensitivity reactions ... Acute transfusion reaction ... release inflammatory cytokines ... hypersensitivity #reactions
Estimated Incidence of Transfusion Reactions
Graphical Depiction of transfusion reactions ordered from most highest to lowest incidence.
#Diagnosis
of Transfusion Reactions ... of transfusion reactions ... Transfusion #Consent #Reactions
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Penicillin-induced drug reaction ... Dermatitis (ie. reaction ... Allergy #Allergic #Reactions