31 results
diagnosis differential rheumatology oncology management algorithm vasculitis acute anemia dermatology hepatitis injury leukemia liver mds myelodysplastic thrombocytopenia activation allergy aplastic
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
weeks without infection ... lymphocyte > 5000/microL ... • Richter’s Syndrome ... Leukemia #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... -> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome ... Vasculitis • Infection ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... ) (e.g. lupus, CLL ... differential #diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... procedures - Infection ... not required in all ... or if a primary hematologic ... #Workup #hematology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Diagnosis • Infectious ... breast CA, small cell ... Vascular: Budd-chiari syndrome ... Differential #Diagnosis #causes ... #hepatology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... Thrombocytosis): • Acute infection ... Myelodysplastic syndrome ... myeloid leukemia (CML ... #hematology #secondary
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... risk-stratification • Risks: infection ... Allogeneic stem cell ... Management #treatment #hematology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Parenchyma • Infectious ... obstruction, HELLP Syndrome ... Disease, Sickle Cell ... Acute #algorithm #hepatology
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
Causes of Knee Effusions ... Weight loss - DDX ... Seronegative Reactive Syndrome ... Effusions: - Hematologic ... Knee #Effusions #causes
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