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Diffuse large B cell lymphoma (DLBCL) - Management and Treatment Algorithm

By Matthew Ho, MD PhD @MatthewHoMD

#Diffuse
cell lymphoma (DLBCL ... Bcell #lymphoma #DLBCL
Lymphoma Classification
Non-Hodgkin - T-Cell Lymphoma
Non-Hodgkin - B-Cell Lymphomas:
 • Highly Aggressive - Burkitt, Aggresive
 • Aggressive
• Aggressive - DLBCL
Causes of Superior Vena Cava (SVC) Syndrome 
Malignant Causes (2/3 of cases)
 - 95%
Lymphoma - DLBCL
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
B-cell lymphoma (DLBCL
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
: Transform to DLBCL