9 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... Clotmaster #VTE #DOAC ... #Oral #Anticoagulant ... #Anticoagulation ... #Loading #DVT #
Anticoagulant specific factor inhibition. 

#anticoagulation #clotting #INR #heparin #LMWH #NOAC #warfarin #coumadin #rivaroxaban  #Xarelto #apixaban
Anticoagulant specific ... #anticoagulation ... #clotting #INR ... heparin #LMWH #NOAC ... #rivaroxaban #
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
of Oral Anticoagulant ... Agents Warfarin ... Hepatic, 35% Renal #DOAC ... #NOAC #Metabolism ... #Pharmacology #
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Anticoagulants Common ... Reversal Agents - Warfarin ... Protamine sulfate - Dabigatran ... Edoxaban (Lixiana), Rivaroxaban ... #doac #noac #pharmacology
Oral Anticoagulation Management Cheat Sheet: Warfarin, Apixaban, Dabigatran, Rivaroxaban
 - Mechanism of Action
 - Routine Blood
Sheet: Warfarin ... , Apixaban, Dabigatran ... , Rivaroxaban ... #Anticoagulant ... #DOAC #Management
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
and Novel Oral Anticoagulants ... or a new oral anticoagulant ... traditional oral anticoagulant ... Heparins #LMWH #UFH #DOAC ... #NOAC #Mechanism
Anticoagulant Bridging

 • Switching from LMWH
 • Switching from UFH
 • Switching from DOAC to Warfarin
Anticoagulant Bridging ... Switching from DOAC ... to DOAC (No Bridging ... Kfischer_10 #Anticoagulant ... #Bridging #anticoagulation
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
For patients on warfarin ... direct acting oral anticoagulants ... to assess for anticoagulant ... determine timing of DOAC ... postoperative #DOAC
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
of Direct Oral Anticoagulants ... concentrations of dabigatran ... ; ECT = ecarin clotting ... thrombin time #doac ... #noac #anticoagulation