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diagnosis hematology differential aflp hellp obstetrics table autoimmune disease hemolysis thrombocytopenia ttphus agglutinin algorithm causes cold deficiency extravascular ferritin hepatitis
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... (7-8%) DAT-negative ... #Anemia #AIHA # ... Diagnosis #Table #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... IgG mediated - DAT ... IgM mediated - DAT ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) - HELLP syndrome ... uremic syndrome ... - Autoimmune (AIHA ... #anemia
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
TTP/HUS, HELLP Syndrome ... (AFLP) Three syndromes ... defects. 1) HELLP (Hemolysis ... AFLP #obstetrics #hematology ... diagnosis #table #comparison
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA ... , Cold AIHA, Transfusion ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Three syndromes ... critically ill pregnant ... defects. 1) HELLP (Hemolysis ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency Anemia ... extravascular) hemolysis ... Gastrectomy, WHDA syndrome ... intake: Anorexia, Pregnancy ... Iron #Deficiency #Anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... Cold Agglutinin Syndrome ... • Symptoms of anemia ... anemia • Cold ... #anemia #hematology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
necrosis HELLP Syndrome ... (Hemolysis, Elevated ... clinical features: Hemolysis ... #hepatology #obstetrics ... #hepatitis #comparison
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoantibodies: • WAIHA ... Coagulopathy) SMZL: • AIHA ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology
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