9 results
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
anaphylaxis is mast cell activation ... Inappropriate mast cell activation ... cells • ANS activation ... #Anaphylaxis #pathophysiology ... #immunology
How dendritic cells (DCs) orchestrate adaptive immunity
1- Sensing of microbial and damage signals by DCs
2- Phenotypic
changes during DCs activation ... adaptive #immunity #immunology ... #pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
of antibodies, activation ... #Inflammation #pathophysiology ... #immunology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
because T-Cell activation ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
cells exposed to activation ... #asthma #pathophysiology ... #inflammatory #immunology
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
lectin pathway activation ... and meninges -> Activation ... C5C9Deficiency #Complement #pathophysiology ... #immunology
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
triggering their activation ... enhance B cell activation ... see Complement Activation ... Humoral #Immunity #pathophysiology ... #immunology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Inhibit B.adrenergic activation ... inotropy) ACCP Cardiology ... Classification #Classes #pathophysiology ... #cardiology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Inhibit B.adrenergic activation ... inotropy) ACCP Cardiology ... Classification #Classes #pathophysiology ... #phases #cardiology