19 results
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
elbows/wrists and knees ... skin thickening Signs ... (interstitial lung ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... effusion, Restrictive lung ... defect (rare) Raynaud's ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
rendering the immune system ... Physical Exam/Signs ... Scoring system: ... Warm AIHA • Bone ... workup #oncology #hematology
Diagram of different types of bone tumors that can occur around the knee on XRay -
occur around the knee ... Healed NOF • Giant cell ... blade of grass sign ... @docskalski #Knee ... #Differential #Radiology
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Pain in Sickle Cell ... long bones ... • Differentiate ... SickleCell #Disease #differential ... diagnosis #causes #hematology
Malignant Bone Tumors: Pathogenesis of X-ray appearance

 • Metastatic bone tumors (aka. cancerous cells from systemic
cancerous cells from systemic ... • Lung. thvroid ... Signs/Symptoms: ... and tumor (Ill-defined ... BoneTumors #Malignant #Radiology
Diagram of different types of bone tumors that can occur around the knee on XRay
Age <
occur around the knee ... Healed NOF • Giant cell ... blade of grass sign ... Lesions #Bony #Differential ... #Diagnosis #Radiology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Myositis 4% - Lung ... (aPL) 30-45% Differential ... autoantibodies #signs ... #rheumatology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
approximately how long ... Intrinsic RBC defects ... (e.g. sickle cell ... Production #Index #hematology ... #anemia #differential
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
sx + signs/sx of ... very remarkable w/differential ... day, followed by long ... them, but urgent rheumatology ... GCA #Temporal #Signs