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rheumatology hemophagocytic lymphohistiocytosis treatment adult algorithm aosd classification dermatology dress hodgkins incomplete kawasaki lymphoma macrophage mas oncology onset pediatrics polychondritis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... frequently affects infants ... age, however the disease ... following: • Fever ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... • HLH Labs: ... Histopathologic criteria ... #Syndrome #Diagnosis ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... • Clinical: fever ... • Autoimmune diseases ... #management #treatment
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
incomplete Kawasaki Disease ... Infants ≤6 months ... old on day ≥7 of fever ... within 10 d of fever ... #Diagnosis #Peds
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Onset Still's Disease ... - Yamaguchi criteria ... a sore throat, ... #rheumatology # ... management
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Criteria for Diagnosis ... Fever >38.5 2. ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis ... #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... number of sites of disease ... through Ann Arbor criteria ... classification #hematology ... #oncology #management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Nonspecific symptoms: Fever ... and fatigue Criteria ... Sarcoidosis • Behcet disease ... /EGPA • RA Diagnosis ... #diagnosis #management
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