13 results
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Anemia • ... • Rheumatoid Arthritis ... • Somatization Disorder
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
- Differential ... malignancies • Anemia ... inflammatory disorders ... (e.g. autoimmune ... #hematology #secondary
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Approach to Joint Pain ... History: Is the pain ... : • Acute or chronic ... #MSK #rheumatology ... approach #workup #differential
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... Mechanical/degenerative disorders ... weeks) Can Be Caused ... Joint #pain #Differential ... #Diagnosis #MSK
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Nail Disorders secondary ... Iron deficiency anemia ... discoloration) • Chronic ... #Differential # ... Diagnosis #Algorithm #causes
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
- Secondary to Chronic ... Ricketts - Diffuse Pain ... • Bone Marrow Disorder ... Fractures #Pathologic #MSK ... #Orthopedics #Causes
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint Pain ... Like in this case ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... . hematologic) ... : • Joint pain ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
syndrome is a rare chronic ... inflammatory disorder ... lesions + Rheumatic pain ... nonerosive inflammatory arthritis ... Rule out other causes
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
very remarkable w/differential ... systemic complaints- anemia ... claudication: pain ... chews, not just pain ... identifies 85 to 95% of cases