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diagnosis hematology differential monoclonal oncology activation gammopathies globulin macrophage mas multiplemyeloma nonpalpable palpable paraproteinemias polychondritis protein proteingap purpura relapsing sjogrens
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... Pseudohyponatremia • ↓anion gap ... vascular beds-renal ... Paraproteinemias #Hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
dL the ULN R - Renal ... Look for gamma gap ... plasmacytoma, POEMs syndrome ... #Gammopathies #MGUS ... #diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... vasculitis - GPA ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... lymphadenopathy • Central ... erythematosus [SLE ... #Diagnosis #Management ... #Hematology #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Gammopathy Include: • MGUS ... changes (POEMS syndrome ... cancers, HCC, renal ... gastric tumors • Hematology ... differential #diagnosis #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Xerostomia • Dental ... lubricants • Pharmacologic ... #Rheumatology # ... Diagnosis #Management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cases such as: • SLE ... Heart failure • Renal ... • Lymphoma • GPA ... Polychondritis #rheumatology ... #diagnosis #management
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