Dermatitis skinrash classification differential hematology rheumatology algorithm thrombocytopenia hemolysis vasculitis dermatology extravascular evaluation agglutinin testing

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Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Agglutination - Cold agglutinins ... Schistocytes, thrombocytopenia ... cardiac valve, vasculitis ... #workup #hematology ... #testing

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cryoglobulins (Vasculitic ... Positive Coombs testing ... younger pts) Differential ... the RBCs causing intravascular ... #anemia #hematology

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