11 results
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
anemia, Penicillin-induced ... Gravis, Graves' Disease ... complexes • Ex: Systemic ... Lupus Erythematosus ... #Types #Classification
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... Pigmented Purpuric Dermatosis ... #Diagnosis #hematology ... #rheumatology #
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Schistosomiasis - Chronic hemolytic ... anemia - Persistent ... neurofibromatosis, vasculitis ... #Diagnosis #Differential ... #Causes
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
lgE causes mast-cell ... disease of the ... glomerulonephritis, Systemic ... lupus erythematosus ... #classification
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... lupus erythematosus ... #classification ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... tract, and often causes ... lupus erythematosus ... #rheumatology # ... classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... • Type-I Interferonopathies ... lymphopenia, low PLT • Anemia ... #Diagnosis #Rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... • Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... ischemia • Skin: Erythematous ... tract, and often causes ... - interstitial keratitis ... #Rheumatology
Erythemas Summarized
Erythema ab igne
 • A dermatosis that results from repeated exposure to heat (fires, heating
Erythema ab igne • A dermatosis ... form of delayed-type ... of necrotizing vasculitis ... presenting with erythematous ... comparison #table #differential