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diagnosis oncology anemia common cvid extravascular hemolytic hodgkins hypogammaglobulinemia immunodeficiency immunology intravascular monoclonal nonpalpable palpable paraproteinemias polychondritis purpura relapsing variable
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... (HUS) • Other ... e.g. lupus, CLL, lymphoma ... #differential # ... diagnosis #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Acquired von Willebrand ... and Management ... disorders (e.g. lymphoma ... #treatment #hematology ... #differential
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic ... Pigmented Purpuric Dermatosis ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... angioedema • vWD • acquired ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... Immunohistochemical studies (to differentiate ... Treatment • Early ... #hematology #oncology ... #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Nodules • Lymphoid ... severe community-acquired ... and autoimmune hemolytic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
involved because it has ... Viral infection • Lymphoma ... affected tissue Treatment ... Polychondritis #rheumatology ... #diagnosis #management
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