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hematology oncology management approach arthritis bcnie bloodculture encephalopathy endocarditis erythematosus fungal gap globulin infections joint lupus lymphocytic mds msk mycoses
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... Chronic leukemia ... extramedullary disease ... bruising, bleeding, infection ... #Diagnosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute ... infection • Solid ... Myelodysplastic syndrome ... myeloid leukemia ... #Diagnosis #Causes
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... weeks without infection ... ’s lymphoma or acute ... #CLL #Chronic ... #diagnosis #workup
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
• Infection with ... special media) • Infection ... Diseases Fellows ... #differential # ... workup #infectiousdiseases
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
with bacterial infection ... prosthetic joint infection ... Joint #Pain #MSK #rheumatology ... #approach #workup ... #differential #
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Marrow Failure • Chronic ... Cell Leukemia ... Myeloproliferative Disease ... • Parvovirus infection ... #diagnosis #hematology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Preeclampsia, Eclampsia, Infection ... Shock, Autoimmune disease ... Reversible course Differential ... Infection, Electrolyte ... #neurology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... fibromyalgia) • Infections ... with Lupus: • Chronic ... Hodgkin lymphoma and leukemia
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
affects the skin, neurologic ... Eosinophilia, asthma, chronic ... tract, and often causes ... , recent viral infection ... #Diagnosis #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... Include: • Viral infections ... Gap #ProteinGap #differential ... #diagnosis #hematology
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