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anemia hemolytic rheumatology agglutinin classification cold common cvid dermatology hodgkins hypogammaglobulinemia immunodeficiency immunology intravascular lymphoma nonpalpable oncology palpable purpura variable
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections ... #Causes #differential ... #diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... SLE) - Viral infections ... APLS • Acute Infectious ... : Schamberg Disease ... #Diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Due to Viral infection ... Polyclonal - Viral Infection ... Diagnosis: • hemolytic ... Check For: • Infections ... #hematology #diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Chronic lung disease ... • Infectious ... Granulomatous disease ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
rheumatic diseases ... to exclude are infections ... Recurrent middle ear infections ... , recent viral infection ... #Diagnosis #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... • Autoimmune disorders ... number of sites of disease ... classification #hematology ... #oncology #management
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