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rheumatology classification dermatology cryoglobulins dermatologic erythematosus granulomatosis hematology monoclonal nephrology oncology paraproteinemias pulmonary rash skin sle systemic types
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
: • Immune Complex ... Urticarial/LCV) - Cryoglobulinemic ... - Microscopic polyangiitis ... - EGPA - GPA ... Disease • Cogan syndrome
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Renal Syndromes ... ANCA-positive vasculitis ... ANCA-negative vasculitis ... IgA-associated vasculitis ... #Syndrome #differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... • Microscopic Polyangiitis ... Necrotizing, pauci-immune ... • Urinalysis (Renal ... differential #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... - GPA, EGPA, microscopic ... polyangiitis ... • IgA vasculitis ... • Vasculitis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
vasculitis Skin ... Diagnosis: Vasculitis ... Granulomatous vasculitis ... • Necrotising vasculitis ... leukocytoclastic vasculitis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... pulmonary and renal ... Differential Diagnosis ... MPO > PR3 60/ GPA ... / ANCA + MPO) Cryoglobulinemic
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
gangrenosum • Cutaneous ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... to cold IgG • Lupus ... vascular beds-renal
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
vasculitis, rheumatoid ... context of primary immune ... • Mesenteric vasculitis ... APLA/LAC: • Renal ... Vasculitis: •
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