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diagnosis hemolytic cold dermatologic dermatology erythematosus extravascular gpa granulomatosis hemolysis polyangiitis rash sle systemic vasculitides
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... usually IgG) (e.g. lupus ... . primary cold agglutin ... #Causes #differential ... #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Syndrome (CAS): ... Clinical Presentation ... younger pts) Differential ... #anemia #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... • Goodpasture syndrome ... disease • Non-Hodgkin ... rash #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... fibromyalgia) • Infections ... cyclophosphamide) • Hodgkin ... Erythematosus #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... Others: • Lupus ... to exclude are infections ... #rheumatology # ... classification
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