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diagnosis hematology hemolytic causes cold dermatologic dermatology erythematosus extravascular gpa granulomatosis monoclonal oncology paraproteinemias polyangiitis sle systemic vasculitides
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgG) (e.g. lupus ... . primary cold agglutin ... #Hemolytic #Intravascular ... #Causes #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Syndrome (CAS): ... Clinical Presentation ... #disease #hemolytic ... #anemia #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Others: • Lupus ... mucositis - Rash ... to exclude are infections ... #rheumatology # ... classification
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... reticularis Differential ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome ... #diagnosis #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... • Coombs (-) hemolytic ... anemia due to cold ... IgG • Lupus anticoagulant ... #Monoclonal #Differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Classification: ... permanent alopecia Differential ... fibromyalgia) • Infections ... lymphopenia, low PLT • Anemia
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... , mucositis • Rash ... infiltrates/cavities, hemoptysis ... / ANCA + MPO) Cryoglobulinemic ... #Rheumatology
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