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hematology anemia cold cryoglobulins dermatologic erythematosus extravascular gpa granulomatosis hemolysis hodgkins intravascular lymphoma management monoclonal nonpalpable palpable paraproteinemias polyangiitis purpura
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
pallor, dyspnea, and ... Diagnosis: • hemolytic ... hemoglobinemia and ... #disease #hemolytic ... #anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgG) (e.g. lupus ... . primary cold agglutin ... , Copper and lead ... #differential # ... diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... Pigmented Purpuric Dermatosis ... /HSP • Cryoglobulinemia ... #Diagnosis #hematology ... #nonpalpable #dermatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
temperatures below 37°C and ... endothelial injury and ... Syndrome: • Clinical ... diseases: - 10% ... ) • Types II and
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... ) pattern: antibodies ... differential #diagnosis ... #rheumatology # ... classification
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Amyloidosis and ... histiocytosis, and ... @KirtanPatolia and ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA) is common and ... GPA causes disease ... Rarely dominate the clinical ... Diagnosis: Vasculitis ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Classification: ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... fibromyalgia) • Infections
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... Hodgkin Lymphoma - Clinical ... nodosum • Immune hemolytic ... number of sites of disease ... #hematology #oncology
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