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anemia hemolytic causes cryoglobulinemia erythematosus hemolysis intravascular monoclonal paraproteinemias sle systemic types vasculitides
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... agglutin disease ... #Causes #differential ... #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Agglutinin Disease ... Agglutinin Syndrome ... #agglutinin #disease ... hemolytic #anemia #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... • Autoimmune diseases ... (e.g. systemic lupus ... #classification ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
to exclude are infections ... Serologies for Cryoglobulins ... differential #diagnosis ... #rheumatology # ... classification
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
anemia due to cold ... IgG • Lupus anticoagulant ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Classification: ... permanent alopecia Differential ... fibromyalgia) • Infections ... #Rheumatology
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