8 results
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
- Takayasu arteritis ... - hypersensitivity ... - systemic lupus ... erythematosus ... Vessels #Diagnosis #Rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... vasculitis, rheumatoid ... Non-autoimmune rheumatologic ... Chronic B-cell activation ... #Diagnosis #Rheumatology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus ... erythematosus ... - Contact dermatitis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
inflammation Others: • Lupus ... such as systemic lupus ... erythematosus, ... LFT • ESR • ANA ... differential #diagnosis #rheumatology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
to complement activation ... Examples: Rheumatoid arthritis ... glomerulonephritis, Systemic lupus ... erythematosus Type ... Examples: Contact dermatitis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
arthritis) • ... • Hypersensitivity ... (e.g. systemic lupus ... erythematosus ( ... classification #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... erythematosus ... erythematosus [ ... • Drug-induced hypersensitivity ... #Rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
GCA (Giant Cell Arteritis ... ischemia • Skin: Erythematous ... inflammation Hypersensitivity ... - interstitial keratitis ... Differential #Diagnosis #Rheumatology