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chronic hemolytic leukemia lymphocytic agglutinin cold cvid dermatologic erythematosus gap globulin gpa granulomatosis hemeonc hemolysis hodgkins hypogammaglobulinemia immunodeficiency immunology intravascular
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... coagulation (DIC ... ) (e.g. lupus, CLL ... #Causes #differential ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Lymphocytosis on CBC ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
3 Types of Cold ... Cold Agglutinin Syndrome ... Viral Infection Clinical ... symptoms - most common ... #hematology #diagnosis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... • Goodpasture syndrome ... Polyangiitis #GPA #dermatology ... #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... Vmphocytosis on routine CBC ... lymphoma (Richter ... #hematology #hemeonc ... #diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... (NSHL) - (most common ... #diagnosis #classification ... #hematology #oncology ... #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... autoimmune hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology ... #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... • Type-I Interferonopathies ... titers > 1:80 • CBC ... common • Antihistone ... #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... gastric tumors • Hematology ... anemia • Other ... Comment on type ... #diagnosis #hematology
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