8 results
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA ... GPA causes disease ... Diagnosis: Vasculitis ... #dermatology #rash ... #diagnosis #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... - GPA - EGPA ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... • Autoimmune diseases ... - GPA, EGPA, microscopic ... #types #classification ... #rheumatology #
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
- Protein Gap ( ... globulin gap (> ... gastric tumors • Hematology ... Comment on type ... #diagnosis #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
> PR3 60% • GPA ... • ANCA (Dx: GPA ... differential #diagnosis ... #rheumatology # ... classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... • Type-I Interferonopathies ... common • Antihistone ... #Diagnosis #Rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cold insoluble globulin ... Divided Into Two Types ... malignancies, vasculitis ... #rheumatology # ... hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
3 Types of Cold ... Cryoglobulins (Vasculitic ... Cold Agglutinin Syndrome ... symptoms - most common ... #hematology #diagnosis