6 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANAAutoimmune ... context of other symptoms ... Primary Biliary Cirrhosis ... #rheumatology #diagnosis ... #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Diagnosis: • ANCA-associated ... rheumatologic diseases ... pancreatitis, protein-losing ... : • Symptoms limited ... #Diagnosis #Rheumatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Signs and Symptoms ... progresses • +AMA ... PBC Diagnosis ... 1.5 x ULN • AMA ... #hepatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often causes arthritis ... Presentation - Systemic Symptoms ... purpura: strong sign ... ) pattern: antibodies ... #diagnosis #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
changes (POEMS syndrome ... : Cirrhosis, ETOH ... , PBC, PSC, Viral ... gastric tumors • Hematology ... #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... • Nonerosive arthritis ... statins - probably caused ... : • PBC, autoimmune ... Myositis #Myopathy #rheumatology