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diagnosis hematology approach causes classification disease effusions hodgkins knee leukemia lymphoma management mds myelodysplasia myelodysplastic physicalexam plasmacytoma sicklecell solitary syndromes
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Cell Disease Vaso-occlusive ... Osteomyelitis / Septic Arthritis ... • Differentiate ... #Joint #Pain #SickleCell
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Number of Joints ... Send for cell count ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
• Ligament • Bone ... the subchondral bone ... #Pain #MSK #rheumatology ... #approach #workup ... #differential #
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
pain, fever, joint ... pain, bleeding, ... manifestations, hypoxia, CXR ... #Leukemia #Hematology ... #Oncology #Diagnosis
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
Knee Effusions - Differential ... Fever/Chills/Joint ... pain/Night sweats ... - Aneurysmal bone ... #diagnosis #msk
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Workup: • Complete ... blood count with differential ... Syndromes #diagnosis #hematology ... #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
hemolytic anemia • Pain ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... anymore • Routine bone ... #oncology #management
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
presents with pain ... thoracic more than lumbar ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology
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