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diagnosis management differential leukemia algorithm chronic lymphocytic mds monoclonal myelodysplastic aortitis aplastic arteritis classification common cvid dermatology erythematosus extravascular gammopathies
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... diseases, CML, ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... Allogeneic stem cell ... #hematology #oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Diagnosis #Algorithm #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... lymphoid organs When Cancer ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... cells can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... ) (e.g. lupus, CLL ... differential #diagnosis #hematology ... #anemia
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Vasculitides: Giant Cell ... arteritis, Cogan's Syndrome ... : IgG4-Related Disease ... : Cancer, Histiocytic ... Differential #Diagnosis #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... Myeloproliferative Disease ... factor (GCSF) treatments ... #diagnosis #hematology ... #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... chemotherapy for low-risk disease ... marrow failure with anemia ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... Constitutional Syndromes ... Treatment: ... #oncology #hematology
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