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diagnosis differential management rheumatology elevatedmcv macrocytic macrocytosis syndrome arteritis cell chronic classification cryoglobulinemia cryoglobulins dermatology disease fatigue giantcell laboratory neurology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Algorithm Mean ... of substrate (e.g ... Algorithm by Dr. ... #Workup #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Iron Deficiency (Eg ... Other • e.g ... #Microcytic #Anemia ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Differential Diagnosis Algorithm ... Increased Requirement (e.g ... Liver Disease #Macrocytic ... #Causes #Hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Anemia • ... • Rheumatoid Arthritis ... • Drug Abuse (e.g
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
arteritis (GCA) ... Diagnosis = clinical ... not be subtle e.g ... E.g. 80 yo ESR cutoff ... systemic complaints- anemia
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... the presence of anemia ... inflammatory disease (e.g ... Chemistry profile (e.g ... ANA and RF (if clinical
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Syndrome: • Clinical ... arthralgia, and arthritis ... tissue disorder (e.g
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
and pernicious anemia ... Clinical Manifestations ... unit activity on EMG ... of diazepam • EMG ... EMG Studies:
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... nonerosive inflammatory arthritis ... Rule out other causes ... antiinflammatory properties e.g ... Tetracyclines etc
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
plasmacytoma) Clinical ... red bone marrow, e.g ... • No CRAB - no anemia ... Oncology #Diagnosis #Workup ... #Hematology
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