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diagnosis management aplastic cell chemotherapy cyp3a4 doac inducers inhibitors interactions mds myelodysplasia myelodysplastic pglycoprotein plasmacytoma rheumatology sapho solitary syndrome syndromes
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... - β-lactam antibiotics ... Treatment: ... #oncology #hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
interactions) Cancer-treatment ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
isoniazid) • Antibiotics ... factor (GCSF) treatments ... marrow studies Treatment ... Syndromes #diagnosis #hematology ... #oncology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
and lower jaw Treatment ... syndrome with acne: antibiotics ... antiinflammatory properties e.g ... Tetracyclines etc ... diagnosis #management #Dermatology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
red bone marrow, e.g ... • No CRAB - no anemia ... Bone marrow Treatment ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology
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