11 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
#MSK #Musculoskeletal ... #Complications ... #pathophysiology ... #signs #symptoms ... #diagnosis
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic ... Ill-appearing, vital sign ... Mucocutaneous or ocular ... Immunocompromised #Diagnosis ... Targetoid #Algorithm #Differential
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... scaly annular lesions ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
ulceration • Ocular ... Behcet disease) Differential ... Oral aphthae : SLE ... • Arthritis: SLE ... #management #signs
Non-Infective Endocarditis (NBTE / Marantic Endocarditis)
Non-infective endocarditis is also known as: Non-bacterial thrombotic endocarditis (NBTE), Aseptic
patients with SLE ... vegetation base makes lesions ... absent How can we differentiate ... pathognomonic signs ... #pathophysiology
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
rheumatoid arthritis, SLE ... Ocular- 50%: Ptosis ... life-threatening Differential ... test - Cogan sign ... - Peek sign
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitides - Differential ... Diagnosis Framework ... Syndrome: - Ocular ... purpura: strong sign ... vasculitis, and SLE
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Diagnosis Framework ... Diagnosis: • Systemic ... diseases, such as SLE ... purpura: Strong sign
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... • Bilateral signs ... Evaluate for NMO, SLE ... Disorders: - SLE ... management #neurology #differential
The Neurological Evaluation of a Comatose Patient

Definition:
 • Coma: a state of unresponsiveness; the absence of
consciousness Differential ... • Mutism Pathophysiology ... • Vestibulo-ocular ... • Examine for signs ... caseyalbin #PhysicalExam